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Measuring the receptor occupancy of a given target showcases the power of flow cytometry. With the right reagents, best practices, and attention to detail, this assay can become a mainstay in your research toolkit. It extends quantitative flow cytometry to the next level, to determine a complete biological picture of how efficiently a given target is being bound. This also serves as the basis for even more fine-analysis when combined with assessment of downstream targets that the engagement of the receptor by the target antibody may affect. Phosphorylation, cell cycle arrest, and protein expression are all within reach, resulting in an even more complete picture of the process, that will ultimately give the medical community a fuller understanding of how these potential therapeutics work and when to use them. This is truly personalized medicine at its fullest potential.

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Some technological advances are incremental, while others are significant game-changing tools that offer the researcher the ability to significantly improve current assays while allowing for new and novel avenues of research to be performed. With speed, sensitivity, and capacity to spare, the ZE5 fits into the game-changing category. Reduced carryover, increased speed of acquisition, and a large number of parameters all open up new and novel assays while improving the quality and reproducibility of ongoing ones.

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